Recalling painful memories while under the influence of the drug metyrapone reduces the brain’s ability to re-record the negative emotions associated with them, according to University of Montreal researchers at the Centre for Studies on Human Stress of Louis-H. Lafontaine Hospital. The team’s study challenges the theory that memories cannot be modified once they are stored in the brain.
“Metyrapone is a drug that significantly decreases the levels of cortisol, a stress hormone that is involved in memory recall,” explained lead author Marie-France Marin. Manipulating cortisol close to the time of forming new memories can decrease the negative emotions that may be associated with them. “The results show that when we decrease stress hormone levels at the time of recall of a negative event, we can impair the memory for this negative event with a long-lasting effect,” said Dr. Sonia Lupien, who directed the research.
Thirty-three men participated in the study, which involved learning a story composed of neutral and negative events. Three days later, they were divided into three groups — participants in the first group received a single dose of metyrapone, the second received double, while the third were given placebo. They were then asked to remember the story. Their memory performance was then evaluated again four days later, once the drug had cleared out.. “We found that the men in the group who received two doses of metyrapone were impaired when retrieving the negative events of the story, while they showed no impairment recalling the neutral parts of the story,” Marin explained. “We were surprised that the decreased memory of negative information was still present once cortisol levels had returned to normal.”
The research offers hope to people suffering from syndromes such as post-traumatic stress disorder. “Our findings may help people deal with traumatic events by offering them the opportunity to ‘write-over’ the emotional part of their memories during therapy,” Marin said. One major hurdle, however, is the fact that metyrapone is no longer commercially produced. Nevertheless, the findings are very promising in terms of future clinical treatments. “Other drugs also decrease cortisol levels, and further studies with these compounds will enable us to gain a better understanding of the brain mechanisms involved in the modulation of negative memories.”
2 weeks ago I had the chance to head to my backyard, San Bernadino for this years Paid Dues Festival presented by MURS 3:16 & Guerilla Union. The all day long party included performances by Mos Def, Talib Kweli, Dom Kennedy, Bun B, Asher Roth, Casey Veggies, Tabi Bonney, Dead Prez, E-40, Skeme, Lil’ B The BasedGod, Nipsey Hussle and many more.
Part 2 of my review of The Paid Dues Festival. Enjoy.
Since all of the kids are doing it I caved and made one after a lengthy debate. Im actually going to take the Lowkey approach and let off my personal thoughts over there with a twist and keep this the usual CSNW business.
So if you got one follow me and ill return the favor.
These huge trees are fully covered with thousands of spiderwebs, something never before seen in Sindh, Pakistan, where this photo was taken. Yes, it’s a eewrifying image, but it has had a surprisingly positive effect on the population of this heavily punished part of the world. How, you scream?
These spiders usually crawl on the ground but, when the massive July 2010 floods took over one fifth of the 307,374 square miles of Pakistani land, they escaped to the trees. The water is taking a long time to recede, so they thought it may be a good idea to adapt to the situation, establish camp and have a big party up there. The results is thousands of cocooned trees all around.
Gross? It is. But the United Kingdom’s Department for International Development thinks that the massive spiderwebs are a blessing and the eight-legged furry beasties are Bill Gates’ new best friends. It seems that these giant sticky pompoms are capturing mosquitoes by the truckload. According to the people in these areas, the mosquito levels are extremely low for this time of the year. Even more so taking into account the vast amount of stagnant water, which acts as a nursery for those bloody winged buggers. As a result, the risk of a malaria plague is a lot lower than what everyone was expecting.
This hits me in my HEART because i knew Carrie on a personal level, we actually were in the same graduating class together. She LOVED Soccer and she had a smile that lit up the room. They MURDERED her over some fucking money man. I hope they catch the suspect very soon. She will FOREVER be missed and NEVER forgotten. RIP CARRIE THOMAS.
Investigators from the Riverside County Sheriff’s Department stand at the scene of a slaying that happened in the parking lot of the Visterra Credit Union in Moreno Valley.
A Shakey’s Pizza manager described as family by the restaurant’s owner was killed in an apparent robbery at a Moreno Valley drive-thru automatic teller machine late Sunday.
Carrie Thomas, 23, of Moreno Valley died at 4:17 a.m. at Riverside County Regional Medical Center, where she was taken after the incident at the Visterra Credit Union branch on Cactus Avenue.
Thomas had worked for the past five or six years at the Shakey’s on Sunnymead Boulevard in Moreno Valley, said owner Harold Veum.
Police captured this image off an ATM where a Moreno Valley woman was robbed and killed late Sunday night.
He described her as being like family and “one of the best managers I ever had,” always arriving at work on time and calling in sick well in advance so a replacement could be found.
“She was cheerful. She could make you laugh so hard,” Veum said. “She could come up with things that just bust your gut.”
Thomas was on the verge of moving into her own apartment, Veum said. “I think she was just getting the keys today.”
He said he spoke with her Sunday night after she closed the restaurant, which has around 40 employees. She was apparently going to the ATM to get money for herself, Veum said.
He added that it was a struggle to open the restaurant Monday. “You can imagine this many employees, just the tears and the hugs,” Veum said.
According to Thomas’ Facebook page, she studied at Riverside Community College and graduated from Vista Del Lago High School. She listed Miley Cyrus as among her favorite musicians.